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The metastatic dissemination involves the acquisition by the malignant cell of an abnormal loss of the tridimensional homeostatic tissue organization.
The pathologic hallmark and malignant cell of classical HL is the multinucleated, giant Reed-Sternberg (RS) cell.
As illustrated in Figure 1A, by immunohistochemical staining of routinely processed pathological specimens, we found that five of the 25 breast tumours were pRB−, that is, loss of pRB staining occurred in every malignant cell of the tumours.
In addition, the possibility for a malignant cell of inheriting P-gp from a normal cell was shown by Rafii et al. in a study where sensitive ovarian cancer cells acquired P-gp by interaction with particular stromal cells isolated from the peritoneal cavity of patients[ 24].
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Before the anti-Notch therapy, the malignant cells of a pancreatic tumor were primitive and aggressive in appearance, with large nuclei, and multiplying profusely.
Fève, M. et al. Comparative expression study of the endo-G protein coupled receptor (GPCR) repertoire in human glioblastoma cancer stem-like cells, U87-MG cells and non malignant cells of neural origin unveils new potential therapeutic targets.
The malignant cells of that bent and twisted journalistic cancer include those who engage in forgeries or other instruments of deceit to obtain information for the purposes of a smear story.
During extensive matrix remodeling in neoplastic progression, SPARC is expressed in cancer-associated stroma and in malignant cells of some types, affecting tumor development, invasion, metastases, angiogenesis and inflammation.
Antibodies to human granulocyte colony-stimulating factor receptor (HuG-CSFR) are widely available and have been used in numerous studies to evaluate the expression of this protein on normal and malignant cells of hematopoietic and nonhematopoietic origin.
In secondary lymphoid organs, Th cells can interact with malignant cells of mature B cell origin, while such interactions between Th cells and malignant immature B cell in the bone marrow have not been described yet.
But unlike the malignant cells of Kaposi's and all the other cancers thought to be caused by viruses, multiple myeloma cells--derived from the bone marrow's antibody-producing plasma cells--don't seem to be directly infected.
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