CARMA3 was reported to be relatively overexpressed in many tumor cells and associated with the malignant behavior of cancer cells (Li et al., 2012; Pan et al., 2016).
Size and mitotic activity contribute to the risk estimation for "malignant behavior" of GIST, according to the National Cancer Institute (NCI) consensus classification [3, 4, 9].
In the event of difficulty in distinguishing between benign and malignant behavior of the lesion, complete surgical resection is critical [2].
Heparanase has generated substantial interest as therapeutic target for antitumor therapy, because its activity is implicated in malignant behavior of cancer cells and in tumor progression.
Inhibition of DNA methyltransferase 1 (DNMT1) can reverse the malignant behavior of cancer cells by restoring expression of aberrantly silenced genes that are required for differentiation, senescence, and apoptosis.
Background & Aims: Alterations in the production of the β-galactoside binding protein galectin-3 and of MUC2 intestinal mucin have been independently correlated with the malignant behavior of human colon cancer cells.
I had been discussing how my laboratory, among hundreds of other labs, was trying to understand how mutations in genes unleash the malignant behavior of cancer cells.
Mutant IDH1 expression can up-regulate hypoxia inducible factor 1α (HIF-1α), a transcription factor that has been implicated in promoting angiogenesis and malignant behavior of cancer cells [13].
We provide evidence that such an interaction induces the secretion and/or activation of endogenous TGF-β by the fibroblasts, which can enhance the malignant behavior of the tumor cells in vivo.
Glutamate, one of the major neurotransmitters in the central nervous system, and its metabolism via receptors and transporters, is thought to be a contributing factor to the malignant behavior of GBM [4], [5].
39 Therefore, downregulation of PML might contribute to the malignant behavior of I-GIST.
