Because of the difficulties of studying the cells in the human brain, it will be tricky to determine whether mast cell malfunctions underlie anxiety disorders, she adds.
However, they are subject to system failures caused by the malfunction of underlying network components.
It is generally agreed that cognitive deficits play an important role in the malfunctioning mechanism underlying the disorder [ 46].
The essential issues of "regulatory malfunctions which underlie neoplasia" remain unresolved but the level of our thinking about them has changed.
Changes caused by aging in these epigenetic states might lead to the malfunctions that underlie the increased prevalence of clinical symptoms of obesity and MetS in the aging population [ 1, 3].
In 1976, in his concluding remarks on Otto Warburg's controversial theory of respiratory impairment in cancer, announced 50 years earlier, Sidney Weinhouse emphasized the need for basic knowledge of the biology of the cell as a way to elucidate the unresolved issues of "regulatory malfunctions which underlie neoplasia".
Some conditions, such as hypertension, involve cutting between normal and pathological parts of a continuous variation, even in the absence of clear underlying malfunctions that separate the populations.
We are people who need earlier diagnosing, better treatments, increased effort by employers to keep us in the workplace and a real attempt to unearth the underlying malfunction behind our symptoms.
However, the diagnoses were listed without worrying about what that underlying malfunction might be, and in most cases there was (and remains) no agreement about what causes what.
DSM diagnoses are usually taken to reflect a conventional concept of disease, despite the talk of underlying malfunction, because of their emphasis on syndromes and their lack of any causal hypotheses.
