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This damage manifested by reduction in follicular region, colloid depletion and malformed follicles.
The exact location of basal keratinocytes and hair follicle bulbs was difficult to discern in knockout mice due to malformed follicles and hyperthickened epidermis.
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Malformed hair follicles, hyperplastic epidermis, and dysplastic mucosal and tongue epithelia were clearly evident in 8 day old mice.
Defective keratinocyte adhesion and malformed hair follicles can trigger a wound healing response in skin, leading to infiltration of inflammatory cells.
Granulocytes, which are rarely detected in control skin (Figure 8C), were also abundant in knockout skin mostly at the dermal-epidermal junction and around malformed hair follicles (Figure 8D and S6).
This finding suggests that once a hair follicle is malformed and has lost the connection to the dermal papilla, it is no longer able to fully regenerate independently of the presence of β1 integrin re-expressing EPCs in the skin.
Splenic hamartoma is a rare benign lesion composed of malformed splenic red pulp elements without organized lymphoid follicles, the exact cause of which is uncertain.
The downless (dl) gene mutations in mice have defective hair follicle induction, lack sweat glands, and have malformed teeth.
In a dish, the follicles that are supposed to contain each developing egg typically end up malformed and clumped together.
There were irregular clumping of pigment in hair shafts, malformed hairs in pilar canals and melanin in macrophages around the base of some follicles.
Is he malformed?
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