Women with undiagnosed type 2 diabetes are significantly more prone to have babies with malformations and may have established diabetic complications (e.g., nephropathy and retinopathy) requiring close follow-up to ensure prompt restoration of normoglycemia.
The lab recently found a gene involved in brain folding thanks to a brain malformation called polymicrogyria that may have enhanced our language ability.
9 However, one limitation was that some malformations may not have been detected and diagnosed at the physical examination after birth.
Although congenital malformation performed well as a marker of severity, it is noteworthy that many deaths resulting from these malformations may not have been prevented even with effective interventions.
Thus, our findings suggest that brain and spinal malformations in monosomy 1p36 may have been underestimated in previous studies.
Although the previous probability of finding a macrovascular cause was lower in patients who did not undergo DSA, some small arteriovenous malformations or dural arteriovenous fistulas may have been missed.
Hypospadias, which is a surgically treated congenital malformation of the male urethra, may have a negative impact on quality of life.
Our study included 2874 women vaccinated during the first trimester and did not find an association between congenital malformations and vaccination status, although this comparison may have been prevented by the low number of malformations diagnosed among vaccinated women (n=35).
