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Congenital malformations have not been demonstrated with the use of narcotic analgesics such as morphine and fentanyl.
These associated malformations have not been reported previously in dogs; whether these two concurrent malformations are part of a single syndrome in dogs remains unknown.
Cervical vertebral fusion defects associated with limb malformations have not been reported in dogs and may be manifestations of a similar condition in humans known as KFS.
Malformations have not been reported in LSFC patients, though they often have distinctive facial features, with a prominent forehead, broad nose and mild hirsutism.
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Also in DM1 patient muscle, mitochondrial irregularities have been found, although the cause of these malformations has not yet been identified [19], [20].
To date, the management of patients with Chiari malformations has not been standardized.
The observed rate of 3% of congenital malformations has not exceeded the rate reported in the general population, nor has any particular pattern of abnormalities emerged.
Moreover, three of our patients had a striking leukoencephalopathy and four patients showed cerebral malformations, which have not been reported in LSFC (Table 1).
However, obvious brain malformations or cognitive developmental delay have not been described in patients with LWD, Turner or Langer syndrome or ISS patients with SHOX haploinsufficiency.
Cervical vertebral malformations associated with limbs anomalies have not been reported in dogs and may represent a condition similar to KFS in humans.
Similarly, studies of congenital malformation in relation to ART have not fallen within the scope of our meta-analysis.
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