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Fetal malformations are known to occur at a dose exceeding 10 rads [3].
Importantly, human cortical malformations are known to result from PAX6 haploinsufficiency (Sisodiya et al. 2001).
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4, 5 The baseline prevalence of major malformation is known to be 1.5 3%.
Both PFO and pulmonary arteriovenous malformation (pAVM) are known risk factors for cryptogenic ischemic stroke in young subjects.
Mutations in cerebral cavernous malformation 3 gene are known to result in development of vascular malformations and have recently been proposed to also give rise to meningiomas.
We have shown that the rates of pre-existing diabetes, chronic hypertension, thyroid disease and asthma were higher than expected among women using antidepressant drugs. 1 6 Among these conditions, the first three are known to affect malformation rate, 6 9 while the association between maternal asthma and infant congenital malformations is weak.
Mutations in ret are known to cause cancer and malformations of the kidney and other organs.
Maternal overweight and obesity are known risk factors for congenital malformations in the offspring [ 60] and elective preterm deliveries [ 61].
Such an effect has been observed for the SHFM1 locus, where the genes DLX5 and DLX6 are known to cause split-hand/split-foot malformation (SHFM).
N-nitroso compounds are known to be potent carcinogens and are known to cause congenital malformations in animal models [ 1- 3].
The custom arrays used contained 112 different human genes that are known to be or potentially involved in MR and congenital malformation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com