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WHS, a relatively common malformation pattern, has been exceptionally diagnosed in fetuses.
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Possible multiple malformation patterns, characteristic of trisomy 21 were sought.
According to Nakanuma's classification, 10 of 29 patients with CoCC showed an area with ductal plate malformation like pattern within the tumor.
10 The CoCC cells sometimes formed antlerlike anastomosing and ductal plate malformation-like patterns.
There was a variety of malformations seen, but no particular pattern of malformations and no apparent dose response relationship.
The above results indicate that Cited2 deficiency induced by Wnt1Cre, Mesp1Cre, or TCre drivers cannot explain either the phenotypic heterogeneity or penetrance of cardiac malformation and left right patterning defects observed in the epiblast-specific deletion of Cited2.
Importantly, among the exposed group, all seven major malformations occurred among the 96 women receiving polytherapy; however, no specific pattern of malformation was found.
The drug safety database analysis showed an overall birth prevalence of 4.39% of congenital malformations in maternal prospective cases, with no specific pattern of malformations.
Eight case reports documenting a unique pattern of malformation in infants prenatally exposed to cyclophosphamide have been published [ 85].
As discussed by Landrigan (4), the pattern of malformation noted has suggested that the critical window of exposure is in the first trimester.
The most common pattern of malformation observed in infants with methotrexate-induced embryopathy includes growth deficiency, craniosynostosis, micrognathia and skeletal abnormalities, which are similar to those in individuals with Miller syndrome [ 21, 22].
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