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If resistance worsens or spreads, our plans to control and eliminate malaria will be foiled.
We know that some ways of dealing with development challenges, such as malaria, will be more successful than others.
There is speculation that announcements of more money for the Global Fund to fight Aids, tuberculosis and malaria, will be made in the coming days.
Completing the eradication of polio in the three countries where it remains and continuing the recent dramatic decline in deaths from malaria will be closely watched litmus tests.
The fund, to fight not only AIDS but also tuberculosis and malaria, will be collected and distributed through a venture involving United Nations agencies, the World Bank and the International Monetary Fund, he said.
He said with confidence: "The world effort to get rid of malaria will be based on this model".
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Our findings provide a molecular explanation for chronic malaria that will be relevant to future malaria-vaccine design and may need consideration when vaccine development for other infections is problematic.
(For the remainder of the paper, the term malaria eradication, rather than the modern term malaria elimination, will be used because eradication was public health terminology for the historical period described).
In this study, the AMA1-C1 malaria vaccine was well-tolerated and did not induce significant vaccine-related adverse events in malaria-exposed adults; however, any successful blood-stage malaria vaccine will be targeted primarily at infants and young children living in endemic areas since they bear the brunt of the morbidity and mortality due to this disease.
While it is difficult to estimate the incidence of true malaria-attributable mortality, it is likely that the mis-classification of malaria deaths will be internally consistent within a study, and thus analysis of percentage age-distributions will suffer less from such errors than would cross-site comparisons.
These deaths underestimate the total burden of malaria on under-fives in the DRC, but they suggest that reductions in malaria endemicity will be accompanied by substantial reductions in child deaths.
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