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In medieval times, spiking fevers caused by deliberate infection with malaria were used to treat syphilis.
Samples from 30 patients older than 18 years old with non-complicated P. vivax malaria were used in the study.
The WHO criteria for diagnosis of severe malaria were used for all Plasmodium species.
Four pooled plasma from clinically immune adult Liberians and two Danish donors never exposed to malaria were used as positive and negative controls respectively.
Data from the largest randomized, controlled trial for the treatment of children hospitalized with severe malaria were used to identify such predictors of a poor outcome from severe malaria.
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In vitro sensitivity assessment of drug combinations for malaria is used to help predict clinically useful combinations.
A serum pool obtained from 30 naïve US donors never exposed to malaria was used to define an assay cutoff; the mean titer +3 SD represented the cutoff value for all negative responses to the PfMSP-119 antigen.
In the pre-antibiotic era, vivax malaria was used to treat patients dying of syphilis, allowing many to make nearly full recoveries.
Serum from volunteers with no history of malaria was used as a negative control and serum from an individual living in a malaria endemic area was used as a positive control for IFA and Western blotting studies.
A truncated 5-day course of PQ for vivax malaria is used commonly in South Asia to reduce the risk of haemolysis and enhance adherence to treatment [12].
Currently, NATs for malaria are used primarily in central health facilities because they tend to be more resource intensive.
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