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A further trial was undertaken in the same study site to compare different treatment regimens and high levels of efficacy against episodes of clinical malaria were observed with each treatment regimen [15].
Spatial and temporal variations of malaria were observed.
In vivo chloroquine resistance was initially reported in the late 1980s and shortly after this period, Day 14 clinical failure rates averaging 5% in children with uncomplicated malaria were observed (17, 19, 20).
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Nevertheless, this issue requires further study since a temporary increase in incidence of clinical malaria was observed in children given long-term chemoprophylaxis [37].
Interestingly, in Sardinia [50] micro-regional accumulation in villages formerly exposed to malaria was observed for carriers of the putative malaria-protective low-activity GR and FMN-dependent pyridoxine phosphate oxidase [50].
The high burden of malaria was observed mostly in health facilities which were located in rural areas, and this important difference has not been detected by the routine care system.
For the rest of the cytoadhesion phenotypes, a uniform trend towards higher levels of cytoadherence among parasites isolated from children with severe malaria was observed, although these differences were not statistically significant.
In the multivariate analysis, a significant association with malaria was observed for the effects of sex, age group, having 2 or fewer bed nets, increased forest cover, elevation and household density was similar to the results observed for the univariate models.
For instance, malaria is observed more commonly in sub-Saharan Africa and India.
In Soweto, South Africa, a significant 1.7-fold increase in the rate of severe malaria was observed (37 ).
The symptomatic group consisted of individuals with relatively mild malaria symptoms and low parasitemias and no single case of truly severe malaria was observed in the area.
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