The efficacy and safety of the antimalarial ACT As+SMP, administered in the doses used for the treatment of malaria, were compared to the efficacy and safety of PZQ, the standard treatment for schistosomiasis, in children aged 6 to 15 years.
We conducted an unmatched case-control study, in which 100 children with cerebral malaria were compared with 132 with uncomplicated malaria and 120 with no malaria.
In the current study, no significant difference was found in the platelet counts when patients with severe malaria were compared with those who had uncomplicated disease.
Latency periods, estimated as the time between entry into the UK and diagnosis of malaria, were compared between the two groups.
The relationship between the MSA and CAM scores and risk of death and severe ICU malaria were compared using chi-square.
Pharmacokinetic parameter estimates for the pregnant women with malaria were compared with estimates for the same women when studied post partum and without malaria using the Wilcoxon matched-pairs signed-ranks test in STATA v.10.
Incoming data on clinical malaria are compared with a baseline of historical illness data from which the effects of long-term temporal trends have been removed, and an objective anomaly measure, or "standardized departure," is used to provide a simple, intuitive index of deviation from expected weekly levels of incidence (3 ).
Genotype data were collected from family trios consisting of one affected child and his/her two parents, and the genotype distribution observed in the severe malaria cases was compared to its expected distribution derived on Mendel's law of segregation.
Annual malaria incidence was compared by using negative binomial regression analysis, except for April 2007 March 2008, when it was compared by Fisher exact test because no cases occurred during that year.
For years with missing months of incidence data, malaria incidence in the recorded months was compared with incidence in the same months in the reference year (April 2003 March 2004).
