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Associations were corrected for the HbS locus, which exerts a strong influence on severe malaria outcome [38], [39].
A careful balance of pro- and anti-inflammatory cytokine levels appears to be critical to malaria outcome [23].
A number of authors shared individual-level datasets, or a more detailed age-breakdown of malaria outcome data than was publically available.
Nevertheless, the ethnic composition did not differ among patient groups (Kruskal-Wallis Test, P-Value = 0.56) and there was no association between ethnic groups and malaria outcome (Chi-Square test, P-value = 0.74) suggesting that ethnic ancestry was not a major factor in stratifying the clinical malaria phenotypes.
The PRET trial is a multicenter community randomized trachoma control trial, with study sites in Tanzania, the Gambia, and Niger 31, 32; for this study, we used malaria outcome data obtained in the Niger site.
We combined reports for specific Plasmodium species into one composite malaria outcome for the overall analysis, but conducted a subgroup analysis comparing outcomes for P. falciparum and P. vivax separately.
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Parental and environmental context associated with severe malaria for children under 5 years of age remains a serious public health problem that affects malaria outcomes in resource-limited areas.
Inhibition of these cytoadherence phenotypes may reduce the occurrence or improve the prognosis of severe malaria outcomes.
The malaria outcomes described are incidence of clinical malaria with fever, numbers of hospital admissions with malaria parasites and numbers of malaria-diagnosed deaths in the community.
We have compiled and analysed available data on P. falciparum malaria outcomes of different severities across all transmission intensities in sub-Saharan Africa.
However, sensitivity analyses of the definition used suggested that sites showed consistent patterns of seasonality for different malaria outcomes and across several years [43].
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