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While the demographic and clinical surveys were able to register basic information as clinical signals and past malaria experience for the residents of all age groups, the parasitological survey enrolled only residents over 5 years of age that accepted to participate in the study, representing 69% of residents with more than 5 years in Candelária and 84% in Teotônio.
It should be reminded that the Beninese women under study cumulated previous malaria experience, and/or that co-infection with other parasitic or bacterial pathogens not investigated in the present study may have occurred, thereby preventing a clear relationship.
We suggest the following hypothesis: A proportion of children suffering from malaria experience loss of the barrier function of the gut due to parasite sequestration (and reduced microcirculatory flow), inflammation or both.
Following the principle of gradual selection, informants were theoretically selected (in accordance with emerging results/theory) and categorized in relation to relevant criteria (such as gender, age, locality, forest activities, previous malaria experience, and use of preventive measures).
In summary, this retrospective study of the 24-month malaria experience of a single hospital in eastern Indonesia suggests P. vivax, along with myriad possible co-determinants, contributes substantially to the burdens of hospitalizations, serious illness, and death associated with the malaria endemic to this community.
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The results of trials in October 2013 showed that the RTS,S vaccine developed by GlaxoSmithKline nearly halved the cases of malaria experienced by children aged between five and seven months and cut the number of cases in babies aged six to 12 weeks by a quarter.
Encouraged by these results, we have undertaken comparative trials of RTS,S/AS01A and of RTS,S/AS02B in malaria naïve [13] and malaria experienced adults [17].
Blood stage antigen (AMA-1 and MSP-1) vaccine studies in malaria experienced individuals demonstrate variable serologic and functional antibody responses, depending on the antigen tested [13], [28], [29].
The study observed that individuals with low knowledge on malaria experienced 2.3 times more malaria cases in their households compared to individuals with higher knowledge.
Published: June 25 , 2015While completing its complex life cycle, Plasmodium, the causative agent of malaria, experiences diverse host environments and undergoes remarkable variation in shape, size, and motility.
(d) Two months postnatal time-point: Maternal ill-health* was indicated by self-report of episodes of diarrhoea or malaria experienced since birth.
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