Participants with severe malaria or danger signs were also treated with quinine.
Patients with evidence of severe malaria or danger signs (convulsions, lethargy, unable to drink or breast feed, repeated vomiting, unable to stand/sit due to weakness) were referred for treatment with parenteral quinine.
Additional selection criteria included: no known allergy or prior adverse reaction to study medications; no onset of menstruation; no fever (axillary temperature <37.5°C) or history of fever in previous 24 hours; no evidence of severe malaria or danger signs; no ongoing antimalarial treatment; hemoglobin >7.0 g/dL; and parasite density ≤10,000/µl.
Their ADDO training covered how to properly identify and treat malaria, recognize danger signs of complicated malaria, refer patients to health facilities, and properly keep records and comply with regulations governing proper dispensing practices.
Health talks are intended to cover nutrition, malaria, STIs/HIV/AIDS, danger signs of pregnancy and delivery, family planning, breastfeeding and care of the newborn.
Children were excluded if they had (i) known allergy or adverse reaction to artemisinin-based regimens; (ii) history of menarche; (iii) fever (axillary temperature ≥37.5°C) or history of fever in the previous 24 hours; (iv) evidence of severe malaria or danger signs; or (v) ongoing antimalarial treatment.
Late clinical failure (LCF) was deemed to be 1) development of severe malaria or danger signs after Day 3, with parasitemia but without previous criteria of ETF; or 2) parasitemia and temperature > 37.5°C on any day between Days 4 and 28, without previous criteria of ETF.
Children were excluded if they had any of the following: 1) known allergy or prior adverse reaction to artemisinin-based regimens; 2) history of menarche; 3) fever (axillary temperature ≥ 37.5°C) or history of fever in previous 24 hours; 4) evidence of severe malaria or danger signs; or 5) ongoing antimalarial treatment.
The strategy is to inform and educate pregnant women on a variety of topics including nutrition, malaria, STIs/HIV/AIDS, danger signs of pregnancy and delivery, and care of the newborn.
There was also no difference in their knowledge of malaria, pneumonia, and danger signs.
Swertia chirayita, which grows in the Himalayas and treats several diseases, including malaria, is in particular danger.
