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The coexistence of HbC and HbS in a hyperendemic malaria context such as Burkina Faso provided a unique opportunity to explore this question in a comparative approach.
This study was conducted within the actual malaria context using field-based data in a malarious population.
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However, none of them are similar to the Ethiopia malaria epidemiological context and to the current national diagnosis and treatment strategies.
Although our results show restrictions on the use of PCT and CRP in a malaria-endemic context, presence of P. falciparum can rapidly be assessed with a RDT.
Therefore, we investigated haemoglobin phenotype-specific immune reactivity to a composite isolate expressing a wide range of P. falciparum VSAs in subjects resident in two different malaria endemic contexts of Burkina Faso.
It is noteworthy that in malaria endemic contexts, most patients coming to hospital have already taken some treatments (self medication prior to admission), a factor which may influence the parasitaemia assessment [37].
In the local socio-cultural context, malaria is interpreted according to humoral illness conceptions and classified as a hot disease.
Two patients were hospitalized for severe malaria in the context of re-infections, one child was hospitalized because of severe asthenia related to the baseline malaria infection, and one patient suffered from convulsions during the night after baseline assessment and was hospitalized.
The team recognised that the standard community entry process had limitations because women were infrequently involved in the process but had an important role in consenting to research involving young children in emergency situations (which frequently involve severe malaria in this context) [ 25].
Admittedly, some of those problems occurring in the postpartum period may be prevented by interventions in the intra-partum period, especially sepsis, and the higher proportion of deaths occurring outside the intra-partum period may be partly attributable to the high prevalence of malaria within this context.
With growing interest in malaria pre-elimination contexts, there is a need to identify and effectively target "hot spots" and similarly "hot populations".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com