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Most patients are of advanced age with attendant comorbidities, making treatment difficult.
Several NTM strains are resistant to many antimicrobial drugs, making treatment difficult (3 ).
These four countries had in general the highest frequency of resistance to most antimicrobial agents, potentially making treatment difficult.
In general, the toxicities are manageable but real, thereby making treatment difficult (Sleijfer et al, 2005; Benjamin 1987).
Current frontline antibiotic combinations require months-long treatment courses, making treatment difficult, particularly in the developing world where access to healthcare can be limited (Sacchettini et al., 2008).
Carbapenem-resistant K. pneumoniae (CRKP) has become a major threat and burden to healthcare systems worldwide as most isolates are resistant to multiple classes and some to all classes of antibiotics making treatment difficult if not near impossible.
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Once inside the system, language and cultural barriers can make treatment difficult.
The need for a host cell to support the multiplication of the virus makes treatment difficult because the agent must be able to inhibit the virus without seriously affecting the host cells.
Severe scorpion envenomation is rare, which makes treatment difficult to study using conventional controlled clinical trials; and small-scale placebo-controlled trials conducted in tertiary centers are of limited generalizability to the community setting.
What makes treatment difficult is the chaos and danger of an attack -- conditions that can be simulated in moulage drills with actors.
Unfortunately, neuroblastoma develops resistance rapidly to chemotherapy agents and makes treatment difficult.
More suggestions(14)
makes treatment difficult
making recovery difficult
making transparency difficult
making comparison difficult
making conversation difficult
making flexibility difficult
making treatment unaffordable
making coöperation difficult
making navigation difficult
making diagnosis difficult
making interpretation difficult
making travel difficult
making life difficult
making business difficult
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com