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A dithioamide BHPTC displayed promising antiproliferative activity in several cancerous cell lines, making this molecule an interesting lead compound for the design of new iron-chelating anticancer drugs.

Plasmodium vivax Duffy binding protein region II (DBPII) is an essential ligand for reticulocyte invasion, thereby making this molecule an attractive vaccine candidate against asexual blood-stage P. vivax.

However, although blockade of VEGF has been proposed to be of potential therapeutic benefit in RA, emerging understanding of other potential functions of VEGF are making this molecule less attractive as a therapeutic target in the clinic.

Recently, the inhibition of chloride intracellular channel 1 (CLIC1) activity was identified as a specific molecular mechanism by which metformin affects only CSC viability, sparing normal stem cells [ 93], making this molecule particularly interesting as novel anticancer drug.

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Moreover, engineering an extra Zn II -binding peptide to the N-terminus of human endostatin makes this molecule more stable and cooperative in the presence of Zn II -binding

Therefore, the overall results validated each method and make this molecule as a potent MMP-2 inhibitor that blocked the invasion and could bring apoptosis at later stages in K562 cells sparing the normal ones.

The pleiotropic effects of melatonin, combined with its anti-oxidant, NMDA-blocking and anti-inflammatory properties, probably make this molecule an ideal candidate for pre-clinical studies.

Interestingly, the capacity of CD22 to internalize specific monoclonal antibodies was shown to make this molecule an effective target for immunoconjugate therapy of B-cell malignancies [51] [53].

The initial bronchoconstrictor effect observed with AZD9164 makes this molecule unfit for its intended purpose.

The physical properties of [F]FDG make this molecule especially useful for intraoperative tumour imaging.

The correlation between the antibody response against it and the asymptomatic status surely makes this molecule an interesting target.

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