More sensitive classifier will have this factor slightly above unity, whereas slow response classifier makes this factor lower than unity.
So it is better to make this factor explicit and see how to deal with it logically.
Although randomization after resin removal made this factor equal in both experimental groups, the presence of remnant resin may interfere with adsorption of nanoHAP particles.
The problem is how to make this factor last -- how to create mechanisms that will continue to work even when a U.S. president or his secretary of state are not around.
Raji cells were pretreated with proteasome inhibitor MG-132 (Merck), for this reagent can block the degradation of phosphorylated IκBα and consequently makes this factor easier to be detected [34].
Along this line, the fact that REST is a transcriptional repressor made this factor a specially attractive candidate to explain the effects observed in miR-9-SpNestin-Cre mice.
NF-κB is both a downstream effector of TLR signaling and it is an upstream regulator of TLR4 expression, making this transcription factor a central molecule in inflammatory regulation.
Moreover, H2O2 and NO formed during CCl4 intoxication also directly modulate NF-κB activation via an IKK-dependent degradation of IκBα pathway, making this transcription factor a central regulatory molecule in regulating CCl4-induced oxidation and inflammation [ 41, 42].
Could our diet be a factor in making this mutated gene become more pathogenic?
Moreover, the level of hepatic Abcc6 expression also determined the severity of postinjury calcification, thus making this an important factor in determining myocardial dystrophic calcification [ 111].
