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Characterizations of astrocytes in culture have pointed to fewer changes, thus making this cell type relatively closer to its initial in vivo state [39].
The PC12 cell line was derived from rat adrenal pheochromocytoma and expresses receptors for, and responds to, βNGF [ 24], making this cell line useful for neuronal differentiation and axon growth studies [ 25, 26].
Our results indicate that the p.R215W mutation in the HCC1395 breast cancer cell line impairs NBN function, making this cell line a potentially useful cellular model for studying defective NBN protein within a mutant BRCA1 background.
KARPAS422, TOLEDO, SU-DHL-4, and OCI-LY-1 display upregulated Bcl-2 levels and high amounts of Bcl-2/Bim complexes, rendering these cells particularly sensitive toward the BH3-mimetic drug ABT-737, whereas PFEIFFER displayed relatively high levels of Bfl-1 and myeloid-cell leukemia 1 (Mcl-1) levels making this cell line more resistant to ABT-737.
The overlap between the human and cell-line differential expression profiles and protein networks was statistically significant showing that the cell-line model reproduces molecular patterns observed in clinical castrate resistant prostate cancer samples, making this cell line a useful tool in understanding castrate resistant prostate cancer.
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Scalability and endurance potentiality make this cell interesting for future high-density and high reliability applications.
The relative "ease of use" and the fact that 90-95% of lung cancers are thought to originate in epithelial cells make this cell line an apt toxicity media for geoscientists [54, 55].
The cell was specially designed to include two piezoelectric transducers and two sapphire windows that make this cell well suited to investigate critical behavior of mixtures, using simultaneously the acoustic technique and the direct visual inspection of the critical opalescence.
The lack of Smad 4 expression in BIC makes this cell line the perfect negative control for transcriptional regulation of the TGFβ pathway.
This reversible immortalization is unique to this urothelial cell line, and makes this cell line the optimal model for the characterization of cell cycle checkpoint activation, apoptosis, and the DNA damage response in urothelium.
These cells in fat body of the larvae have been shown earlier to be capable of surviving complete desiccation even if dissected from the larvae, which makes this cell type a convenient model for studies of anhydrobiosis [37], [38].
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