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Exact(19)
A great challenge facing the pharmaceutical scientist is making these molecules into orally administered medications with sufficient bioavailability.
Characterization has underlined the in vitro antiproliferative character of these compounds on five cancerous cell lines, combining with a high solubility at physiological pH, making these molecules druggable.
The chemokine CXCL12 and its shared seven-transmembrane receptors CXCR4 and CXCR7 regulate diseases including cancer, atherosclerosis, autoimmunity, and HIV infection, making these molecules promising drug targets.
Surprisingly, these compounds exhibited excellent selectively index values ranging from 900 to 1800 making these molecules promising candidates as antiparasitic agents.
We have previously reported that an initial collection of newly generated Trolox-derivatives have improved antioxidant properties as compared to Trolox25, making these molecules attractive candidates for therapy development for mitochondrial diseases.
We demonstrated that curcumin and NDS27 can strongly bind to the enzyme and prevents its assembly making these molecules good candidates for the treatment of horse or human pathologies implying an excessive activation of neutrophils.
Similar(41)
"The basic idea was, 'How do we make these molecules smaller' " without diminishing their effects?
Little is known about their roles, but their high stability and easy quantification make these molecules potential biomarkers.
Furthermore, intensive investigations of the pharmaceutical and toxicological properties of HDACis as anti-cancer drugs make these molecules the most advanced anti-latency agents in clinical trials.
The mechanism of action of the bone morphogenetic protein (BMP) family theoretically makes these molecules candidates for rapidly enhancing local bone structure.
A combination of high antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA), without hemolytic activity and proteolytic stability makes these molecules promising candidates for novel antimicrobial therapeutics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com