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Moreover, meropenem binding induces structural changes in CTX-M-15, making the enzyme less efficient.
It is absent from most somatic tissues but is reactivated in more than 85% of cancers, making the enzyme ideal as a marker of cancer cells and as a therapeutic target.
Halohydrin dehalogenase from Agrobacterium radiobacter AD1 (HheC) displays a broad substrate range with high regio- and enantioselectivity of both ring-closure and ring-opening reactions, making the enzyme a useful catalyst for the production of optically pure epoxides and β-substituted alcohols.
The A version of the gene differs by a few key mutations from B. People with type O blood have mutations in the ABO gene that prevent them from making the enzyme that builds either the A or B antigen.
Rotation of the c-ring occurs due to Brownian motion, making the enzyme a Brownian ratchet.
However, in humans and higher primates, mutations in the uricase gene occurred during evolution and, making the enzyme nonfunctional, resulted in higher levels of serum UA than in other mammals [ 12].
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Other work on both LDH and malate dehydrogenase has suggested that high pressure leads to protein unfolding, making the enzymes more susceptible to proteolysis [14], [18].
Higher water contents may lead to water saturation of enzyme crystals in organic solvent making the enzymes' conformation more similar to a fully aqueous environment [ 21].
BSH knockout bacterial strains are more sensitive to extremes in salinity, pH, and the presence of electrophilic compounds, making the enzymes responsible for BSH biosynthesis attractive targets for combating resistance to fosfomycin.
Monocytes, however, should be able to reach the brain, take up residence there and make the enzyme.
They then screened a large batch of likely chemicals to see if any made the enzyme more active.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com