The rapid pace of methodological development in this area has been coupled with an accumulation of experimental data that makes the elucidation of complex biological networks underlying susceptibility to these common inflammatory diseases a reasonable goal in the near future.
In both inbred and outbred mice many other alleles are presumed to also affect anxiety-like behavior so that the contribution of this duplication would account for only a small percentage of the total trait variance; this is characteristic of all complex traits and has made the elucidation of their molecular correlates a challenging problem.
This makes the elucidation of Xmrk downstream targets a useful method for identifying processes involved in melanoma formation.
The complex speciation pattern has made the elucidation of their relationships a challenging task, and many questions remain unanswered.
Therefore, the significant contribution of VFA to increased BMI and the association of VFA with CRP make the elucidation of its role in PD patient outcomes complex.
This fact, combined with the large number of protein family members (48 genes in humans) and of synonyms (over 100) makes the elucidation of the dimerisation network a non-trivial task.
This complex speciation pattern has made the elucidation of the species relationships a challenging task, and many questions remain unanswered about the tribe composition (e.g. inclusion of Allenopithecus in the tribe), genera definitions (e.g. whether to consider Chlorocebus as a separate genus) and in particular, the phylogenetic relationships among genera and species [ 6, 8, 9].
Two processes, folding of the protein and binding of cofactors, intermingle with each other, making the direct elucidation of the folding mechanism of proteins in the presence of cofactors challenging.
Other substitution patterns are also possible, including N-acetylation and 3-O-sulfation of the glucosamine, as well as non-sulfated iduronate and β-D-glucuronate, and 2-O-sulfation of glucuronate, providing considerable sequence heterogeneity [9] and making the structural elucidation of heparin challenging.
The overall concentration of compounds produced by plant-associated bacteria in roots and the rhizosphere is usually low (usually < 10 μg/g), making the direct structure elucidation challenging.
