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The lack of credible data concerning equipment reliability and the cost of power outages has hindered engineers in making such studies.
Past studies used oral and/or IV routes inconsistently, making such studies, in retrospect, flawed and difficult to interpret [17].
Further, only small numbers of paired study subjects are required to identify differentially expressed genes, making such studies cost-effective.
However, the joint efforts of researchers in the laboratories participating in the ENCODE project [ 23] are now making such studies possible in a few selected cell lines.
An assessment of host biomarkers would require validation work in patient populations with different genetic backgrounds, as ethnicity can influence the composition of the host response, making such studies even larger.
In the general population, loss-of-function variants in CACNA1H are very rare (cumulative frequency of splice site, frameshift and nonsense variants in the ExAC database of 0.06%, resulting in expected compound heterozygosity or homozygosity in about 1 in 2.6 million subjects), making such studies challenging.
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For inelastic scattering, it is only the exceptionally large value of σinc that makes such studies feasible.
Creating harmless strains of the same bacteria that are identical except in their maximum temperature could make such studies a lot easier, he says.
Although data for this study are not yet mature, these differences in clinical trial design make such studies in adjuvant chemotherapy for patients with high-risk prostate cancer novel and promising.
If the aim is to make such studies of environmental change relevant to human societies the method attains its greatest utility if either reliable proxies of human activity can be identified alongside the tephra, or – better still – if the tephra itself can also be identified within relevant archaeological layers.
While it remains to be seen if these attitudes translate into actual purchases made, such studies point to shared values that may push companies to rethink their willingness to source goods based on cost considerations alone.
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