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Therefore, we have refrained ourselves from making such extrapolations.
Nonetheless, it is important for drug reviewers to recognise the limitations of making such extrapolations.
The biological considerations involved in making such extrapolations are discussed, as well as some of the mathematical procedures.
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The need to make such extrapolations has practical applications, such as in determination of the osmotic permeability of nanochannels [26]. .
Based on experimental measurements on man-made materials (mostly plastics and polymers), they also noted: "We are convinced that experiments involving continuously variable loading are poor tests of the extrapolation from step data, because the extrapolation makes such accurate predictions for such experiments that nothing new is learned" (Pg. 70).
The results from in vitro studies in cell lines present a huge challenge in their evaluation and extrapolation to human cancers absent the data to make such a leap.
But to make such a projection on a day of extraordinary declines suggests an uncanny extrapolation at the minimum.
We show on Fig. 3 two examples of such extrapolations, made by Langlais and Mandea (2000).
Various models have supported such extrapolations, including linear and threshold models for low-dose extrapolation and body weight or surface area adjustments for interspecies extrapolation.
We therefore emphasize that the limits of launch and flapping flight are contingent upon morphology; extrapolating limits from qualitative assessments of launch performance is, in our assessment, unwarranted and unsupported, especially when such extrapolations are made from birds to distantly related groups (such as pterosaurs).
Results of such extrapolations have been widely divergent.
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