A key simplifying assumption usually made in methodologies designed for large-scale reverse-engineering [ 20, 21], including ours, is that biological interactions among genes (such as regulator-target relationships) imply statistical dependence at a pairwise level.
If his critique has bite specifically against analytic philosophy, this may be because of a lingering faith in philosophical problems as lasting intellectual challenges that any honest thinker has to acknowledge, and which may be met by making progress in methodology.
Moreover, the rapidity and relative simplicity of the HRMAS technique, well coupled to the inherent reduction of solvents consumption and waste production, represent further elements in making this methodology very attractive for a wide spectrum of scientific investigations.
This process ideally involves end user involvement from the inception of research, starting with shaping of research questions, jointly making decisions on methodology, involvement in data collection, and tools development, and ends with the interpretation and dissemination of findings [ 25].
Since the creation of the EORTC Headquarters in 1974, major advances have been made in the methodology used in the design and analysis of cancer clinical trials.
Basically, two actions were carried out (phase 4): making changes in the methodology and increasing the level of difficulty of the assessment activities.
The mystery substance was sent to Renfrew, who with his team "worked on developing methodology for making this in the lab" and pursued commercial applications, said Jean'ne Shreeve, a University of Idaho chemistry professor who knew Renfrew for more than 50 years.
Detailed observations are made of these alternative methodologies in section 5.
This article aims for a comparative study between two well-known robust design methodologies, making a special emphasis in the control by control interaction effects over optimal operating conditions.
The use of the standardized protocols probably eliminated some of the biases associated with sampling sites using different methodologies making this study powerful in regards to equal effort.
Modern Process Mineralogy has been making significant advances in methodology and data interpretation since it was assembled in the mid-1980s as a multi-disciplined team approach to obtaining mineralogical information from drill core and plant samples so as to infer the metallurgical processing requirements of that ore.
