What makes it troublesome to study is that ESCRT-III is not a stable protein complex.
Moreover heterogeneous cultures clearly affect the differentiation potential of single clones, which makes it troublesome to determine the true degree of multipotency of primary MSC.
For example, when Flickr rolled out an auto-upload feature of its own earlier this fall, it would only begin auto-uploads from that point forward, making it troublesome for new or lapsed users wanting to move their entire photo collections over to Yahoo's photo-sharing site.
Harry: "Well, one of the things which made it troublesome at every turn was that we wanted to make a comedy capable of working on many different levels – rather than there being one joke at a time and all the resources of the material are marshalled towards smashing that joke into your face.
However, the physical and chemical nature and functions of lignin make it troublesome in the utilization and conversion of lignocellulosic biomass.
Some systems are quite large (DeLange and Boucher, 1990; Brown, 1993b), and are used outdoors where heat can be troublesome, making it best to create smoke on cooler days (Brown et al., 1993).
October 14, 1006 November 14, 1060 Angers Geoffrey II, byname Geoffrey Martel, French Geoffroi Martel (born Oct. 14, 1006 died Nov. 14, 1060, Angers, Anjou [France]) count of Anjou (1040 60), whose territorial ambitions, though making him troublesome to his father, Fulk III Nerra, resulted in the further expansion of Angevin lands after his father's death.
The economic slowdown has cut demand for most items, making it less troublesome if an order takes longer to process, or a product takes longer to make.
Zirconium has always been known to release hydrogen when overheated, and that gas will burn or explode at a variety of concentrations, making it particularly troublesome.
The effect is probably a mass form of neurotic compensation, but that doesn't make it any less troublesome to my hypothetical novelist.
Even though advanced PLL designs have solved some of the issues, the present paralleled power system actually contains multiple frequencies as each VSG or frequency-voltage regulated source injects its own intrinsic frequency into grid, therefore, makes it more troublesome for PLL unit to generate a stable grid frequency during the pre-synchronization period.
