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The design of new metal-based drugs is often challenged by physio-chemical properties such as insufficient solubility or hydrolytic instability making it problematic to control their delivery, stability and ultimately their specific effects in vivo.
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This makes it problematic to assume that adoption of accounting systems from an institutional field will result in a steady-state of organizational legitimacy.
That makes it problematic to bring in brands.
Due to lack of electricity it makes it problematic to communicate.
Metadata records are often unavailable for VGI, making it problematic for users to discover data in the VGI system.
Therefore, it is problematic to control confounding factors and make causal conclusions.
It might become problematic to control regional labour market tensions, such as GPs having difficulty finding successors for their practices.
It's safe, and it's very well done, but its casualness with regards to its processes makes it problematic.
The complexity of the situation made it problematic for the FP to make adequate decisions about the goal of the medical treatment.
It was not "good form to do things that make it problematic for others", added Schalke's Horst Heldt.
However, the sensitivity to optimisation of in situ hybridisation makes it problematic for high throughput analysis.
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