In addition, due to the heterozygous nature of many industrial strains, for some complex phenotypes that are difficult to measure, it can be laborious to identify a haploid descendant that exactly recapitulates the parental phenotype.
A heavy pressure, an unexpected weight, making it hard to breathe; laborious, must work to fill my lungs against the pressure pushing down on my chest.
This could make it more difficult for curated databases to leverage 'general purpose' tools and could ultimately slow progress by making it more laborious to incorporate new tools or to upgrade the pipeline supporting the curation workflow.
Written into the statute book during the coalition years to stop the Tories doing the dirty on the Lib Dems or vice-versa, the legislation does make it more laborious to trigger an election.
It takes multiple clicks to unfollow someone, making it a laborious chore to ditch 10 accounts, and you still have hundreds left.
"One thing that amazes students is the making of wire and chains, which did not utilize a drawplate in early antiquity, making it a laborious process to create highly prized items," she said.
Transformation frequencies with NHEJ-deficient strains are often low, making it difficult and laborious to generate enough mutants for library screening.
Genetic conditions are rare in the population and until recently, mutation identification has been laborious, making it difficult to develop precise prevalence estimates.
However, sequencing remains a laborious and expensive technique, making it difficult to obtain answers concerning the genetic composition of serotypes, or newly emerged variants of interest in a timely manner.
Data reevaluation requires access to a large set of patient data, including histological lung biopsies and original CT scans, and often requires a complete search of all medical records, perhaps making it too laborious and costly.
