Sentence examples for making it highly difficult from inspiring English sources

However, DMA keeps paper archives of all the reimbursement cases, making it highly difficult and time consuming to identify the relevant cases to fit the case vignettes.

Owing to the diffuse distribution of intense neuropil staining of AQP4, we could not clearly discriminate AQP4-immunoreactive astrocytes with or without a contact with Aβ, making it highly difficult to count exactly the number of AQP4-expressing astrocytes located in the proximity to Aβ plaques.

Technically, criminal courts can only deal with individual responsibility, which makes it highly difficult to link a foreign state to the crime.

The party's rules for proportional allocation make it highly difficult for her to erase Mr. Obama's pledged delegate lead, even if she sweeps the final 10 contests.

The genetic heterogeneity and the complicated molecular mechanism underlying tumor progression have made it highly difficult to develop sustainable approaches for cancer therapy.

It is found that the adsorption of most considered noble-metal single atoms is very strong at the hollow site above the center of the acetylenic ring of the graphyne sheet and their diffusion away from this site towards its neighboring sites is rather difficult, which makes it highly possible to realize well-ordered and uniformly distributed noble-metal single-atom catalysts on graphyne.

In highland areas, indigenous landholdings are highly fragmented, making it more difficult to recognize collective ownership.

The type of card accepted is highly restricted, making it difficult for older people, particularly African Americans, without access to birth certificates or driving licences to vote.

Even modest upgrades and changes in equipment, he maintains, are highly complex, making it difficult to achieve the required safety standards without extensive domestic expertise in this area.

It is highly echogenic, making it difficult to visualize the posterior segment.

The clinical course of immunoglobulin A (IgA) nephropathy (IgAN) is highly variable, making it difficult to predict which patients are at risk for rapid progression.