That incremental feature adding just made it fragile".
Almost two years ago, Kofi Annan, the United Nations secretary general, warned that suspicion of the globalized economy made it "fragile and vulnerable to backlash from all the -isms of our post-cold-war world: protectionism, populism, ethnic chauvinism, fanaticism and terrorism".
What makes it fragile and what makes it toxic? .
This finding suggests that the carboxyl-terminal region truncation of Tat makes it fragile and sensitive to proteasome-dependent degradation.
However, making a system robust to a particular set of perturbations can make it fragile to other perturbations, which results in 'robust yet fragile' behaviour [ 8].
Over-washing your hair can make it fragile and prone to breaking.
If you drill too far, you will destroy the head entirely or make it fragile enough that it will snap off, making it even harder to get the screw out.
The steam generator is a huge cylindrical object with a 3 m diameter, and to enhance the efficiency of heat exchange, thousands of tubes are inside of it, making it a fragile device vulnerable to various problems.
But when Diederik Samsom, the Labour Party leader, was asked last month whether he still believed the monarchy should be scrapped, it was only with visible embarrassment that he admitted he did a sign of how solid political support for the Dutch royals has become.Spain's on-off relationship with monarchy makes it more fragile than its Dutch counterpart.
Exon-shuffling-derived circRNA (ecRNA), including exon-intron circRNAs (ElciRNAs) consist of 3′ 5′ carbon links throughout the molecule, but circular intronic RNA (ciRNA) contains a 2′ 5′ link in the head-tail joint (Zhang et al., 2013), making it very sensitive or fragile to hydrolysis by debranching enzymes (Table 1).
