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In Britain, retail outlets are demanding discounts from manufacturers, making it difficult to increase profit margins.
Similar arguments could be made regarding slats and slots: making it difficult to increase the L/D ratio at low angles of attack.
Patients in the non-RBF group may have higher glucose variability (34), making it difficult to increase the insulin dose.
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Government restrictions on advertising make it difficult to increase tobacco sales in Canada, pushing Rothmans to look south of the border.
But he noted that the city is still adding a large number of hotel rooms, which will make it difficult to increase occupancy or rates quickly.
"Declines in the major oil fields are going to make it difficult to increase global production levels," he said, "so I think the price will remain on an upward trend".
Moreover, a high-frequency transformer requires numerous power stages, which makes it difficult to increase efficiency and reduce the costs [39].
Trait-lethals make it difficult to increase the affinity of all traits at the same time, because they reduce the affinities to zero.
The highly specialized reproductive behaviour [ 2] and low fertility make it difficult to increase their numbers quickly by breeding in captivity.
Currently, in the private sector only Part 1 pharmacies and ADDOs can legally stock and dispense ACTs, which makes it difficult to increase access to ACTs in regions without ADDOs.
Also, other economic contexts such as high public debt and population growth rate in most of these countries have made it difficult to increase government spending on health [ 2].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com