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Imputation accuracy decreases with MAF, making it difficult to impute very rare variants.
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Results showed that a higher MAF made it difficult to impute SNPs with high certainty and therefore many of those genotypes were not imputed.
"It obviously makes it difficult to shop".
"It makes it difficult to raise money".
That makes it difficult to recommend solutions.
It makes it difficult to say anything.
These properties make it difficult to detect.
It makes it difficult to detect small scaled deformation.
It made it difficult to hear everything.
This makes it difficult to generalize.
This makes it difficult to ensure quality.
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