Sentence examples for making it difficult to fix from inspiring English sources

These mutations can modify the fitness of the genomes where they appear, adding further complexity to the process of interference, and making it difficult to fix any beneficial mutation and the emergence of a defined consensus sequence.

This however makes it difficult to fix the attendant mass fraction (the overall x np is around 1.5 wt.%).

The continuous service execution makes it difficult to fix bugs and add new required functionality on-the-fly as this requires non-disruptive replacement of parts of a software version by new ones [4, 5].

There have been some results reported for the resistivity measured using the four-wire method; however, the surface of bismuth nanowires is oxidized during the fabrication process, which makes it difficult to fix the boundary conditions for the wire diameter direction [12 14].

That made it difficult to get a clear fix on the doctrine.

This makes it difficult to define what is truly "effective".

This makes it difficult to define properties of individual components.

This has made it difficult to define.

Many firm descriptions made it difficult to make judgments.

This makes it difficult to make broad ecological generalisations.

No semi-quantitative method was used to determine the MaR by both T2-weighted imaging and CE-SSFP, since the signal intensities of the MaR and the remote myocardium varied between slices and between patients, making it difficult to choose a fixed standard deviation of signal intensities to differentiate MaR from remote myocardium.