The mountainous terrain and geographic features of El Hatillo have made it difficult to extend the Caracas Metro to southeast Caracas, so the main transportation methods in the municipality are private vehicles and road public transportation.
While naturally occurring mutations have demonstrated a central role for Oas in murine resistance to WNV infection, the radically different composition of the mammalian OAS gene clusters make it difficult to extend this conclusion.
This "curse of dimension" makes it difficult to extend the present model to more species or more sequences.
However, aberrant cellular pH regulation is also a hallmark of many cancers (Harguindey et al., 2005), which makes it difficult to extend these conclusions to other cell types.
This makes it difficult to extend the training period, and in several countries the training course has been shortened [ 32], although this may adversely affect performance[ 23].
In some situations, trees, brush, or anything else that makes it difficult to extend a back cast may limit the movement of your cast.
Taliban commanders often hail from the same villages the army is trying to extend its influence to, making it difficult to persuade residents to shun the insurgents.
Due to the variable geotechnical conditions in these areas, which occasionally cause extensive changes between soil layers within a close distance, the stress-deformation field is very complicated and extended, making it difficult to select and design a proper and safe support system.
At later stages of anaphase, both the number of PICH-positive threads and the hybridization efficiency of the pan-centromere probe to the threads diminished, making it difficult to obtain satisfactory FISH signals on extended threads.
Specifically, the distribution of measures for person extends beyond those for items, making it difficult to distinguish between extreme outcomes.
