Sentence examples for making it difficult to design from inspiring English sources

The distance between raw information and cases lies in the middle of information processing and CBR application, making it difficult to design practical CBR systems.

Concentration effects of XEs are nonmonotonic (a trait shared with natural hormones), making it difficult to design efficient (single concentration) toxicology tests to monitor their harmful effects.

However, biosimilar monoclonal antibodies provide many challenges compared with first-generation biosimilars, growth factors, and hormones, because they have shown only a modest clinical effect, and are often used in combination with other more toxic therapies, making it difficult to design studies that allow appropriate efficacy and safety assessments compared with the original products.

In this context, it is emphasised how the modern approach led to the desegregation of the ocean into two realms, namely the coastal ocean subject to national jurisdiction, and the international ocean, making it difficult to design and operate integrated management.

Characterizing the spatial patterns of gene flow from transgenic crops is challenging, making it difficult to design containment strategies for markets that regulate the adventitious presence of transgenes.

The third intron of lin-11 had no obvious TATA box for transcription initiation, making it difficult to design truncated promoter/enhancers.

Its special characteristics have made it difficult to design instruments capable of performing a non-invasive evaluation of its structure and function in humans.

However, trypanothione reductase has structural similarity with its human homologue glutathione reductase, which could make it difficult to design selective analogues against this enzyme.

However, the high nonlinearity of the modulation sequences contained in q makes it difficult to design.

This complicated conformational transition issue makes it difficult to design optimum linkers for fusion proteins with multiple conformations.

Furthermore, the high order terms appear in a nonlocal operator, which makes it difficult to design an efficient implicit method.