The compact 3D structure of an efficient "enzyme" form makes it difficult to copy, because it requires more energy and time to unfold during replication than in the case of loosely folded strains.
Of the final 10 common SNPs, 7 were within repetitive sequences, making it difficult to sequence a specific copy, and 3 were undetectable in the small population of dms4-1 seedlings tested.
This materialized view [ 1] based alternative has been proven to be expensive and complicated, principally because indiscriminate copying introduces version maintenance problem, making it difficult to correct obsolete information in the copied version when the main copy is corrected.
North Korea's taped replays did not carry the audio or graphics from the original footage, making it difficult to tell whose transmission it had copied.
For the publisher, it's an effort to address the "dark sharing" problem in which scientists and readers share PDF copies, making it difficult to gauge how often they're being read. .
As for de Forest's furniture, no one knows precisely how much was produced, a mystery that deepens when it becomes clear that none was labeled or marked, thus making it difficult to distinguish it from the often fine copies produced by competitors.
These trans-associated dmsD possessed extra annotated ' dmsD' copies (1 5) and/or incomplete DMSO reductase operons frequently lacking the membrane anchor subunit dmsC making it difficult to determine precise associations between the multiple dmsD and dmsABC copies.
However, there are many copies of IS1 and IS911 in the genome, making it difficult to draw any inference of their origins.
While symmetric PCR assays are quantitatively valid for measuring initial sample copy numbers over seven to eight log orders of magnitude [ 5, 6], the reliability of individual assays makes it difficult to quantify copy number differences on the order of one to three [ 6, 7].
This variability in the frequency profiles does unfortunately make it difficult to confidently call copy number variations.
