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Both e-mail transmission dates and text can be easily altered, and because of the vagaries of computer servers, e-mail may arrive hours or days after it was sent, or sometimes not at all, making it difficult to construct a timed paper trail.
However, there are two major obstacles in the way to effective micromarketing strategies: (1) data limitation at the consumer-level making it difficult to construct robust and accurate promotional response function and (2) misplaced usage of a resource allocation approach effective in a data-rich environment to data-challenged environment.
Cucumber has a very narrow genetic base making it difficult to construct high-density genetic maps.
Moreover, these methods generally produce limited markers, making it difficult to construct high density genetic map that is essential for chromosomes assembly.
There is a large variation in different physiologic measures among older adults, making it difficult to construct "normal" limits to differentiate a disease from a normal state.
A drawback associated with the analysis of ESTs is that, within a gene family, some unigenes may correspond to partial sequences, making it difficult to construct alignments of sufficient length for phylogenetic reconstruction.
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Its small size makes it difficult to construct completely in tune and causes what would be small pitch variances in larger instruments to become rather significant.
This early absence of a strong sense of self makes it difficult to construct a memoir.
He added: "One of the problems is that the way central government organises itself, in silos, makes it difficult to construct other ways of organising on the ground.
The lack of a conventional urban core in Los Angeles, along with comparatively low population densities, had made it difficult to construct modern rapid-transit systems there, but work on a subway system in Los Angeles began in the 1980s.
This makes it difficult to construct the computational algorithms.
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