Sentence examples for making inhibition of from inspiring English sources
However, these proteins have little substrate specificity, making inhibition of selected helicases a challenging problem.
Ovarian cancer is a highly aggressive disease, making inhibition of adjacent organ penetration/invasion, which facilitates the dissemination of this cancer, an important therapeutic goal.
Furthermore, we have found that K capsule contributes to multiple aspects of UTI pathogenesis, including intracellular replication [23], making inhibition of capsule biosynthesis a novel target for attenuation of UPEC virulence.
In addition, kinases have proven to be pharmacologically tractable, making inhibition of kinase activity with small molecules a highly effective strategy for cancer treatment (Zhang et al., 2009).
Several studies showed activation of Notch signaling as an early event in the development of pancreatic cancer [ 9– 12], making inhibition of Notch signaling an attractive therapeutic target.
Despite extensive research in the field to understand the pathogenesis of diabetic retinopathy, the exact mechanism(s) remains elusive making inhibition of the progression of this disease a daunting task.
The large therapeutic window between species makes inhibition of human Krs1 a minor concern.
Despite this and other notable successes in this area, the structural homology and functional overlap of the more than 200 glycosyltransferases makes inhibition of individual glycosyltransferases a challenge.
The independence of HDL degradation of SR-BI makes inhibition of HDL degradation a putative therapeutic strategy for raising HDL levels without concomitant inhibition of cholesterol clearance from plasma by selective uptake.
This dual activity makes inhibition of TDP1 a compelling target for clinical studies in combination with Top I inhibitors and radiotherapy, especially when viewed in the context of the early success of PARP inhibition in clinical practice.
Their expression by the majority of EC makes inhibition of HIF1α a very attractive therapeutic option for treating patients with EC and we suggest that it will be prospectively validated in future studies.
