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Because of the similarity between NEK2A, NEK2B, and NEK2C, antibodies for each one are not available, making functional studies of endogenous NEK2A somewhat troublesome.
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Second, their different pigment groups are spectrally well separated, which makes functional studies much easier to interpret compared with chlorophyll-containing photosynthetic organisms.
Most gut microbes are strictly anaerobic and, for much of the last century, fewer than 30% of them could be cultured in the laboratory, which made functional studies impossible.
In addition, transcriptome analysis and RNA-interference studies in cockroaches make functional studies of the molecular clockwork feasible despite of the large, not yet-sequenced genome of this cockroach species.
Furthermore, current policies on the use of non-human primates in research are very limiting, which makes functional studies on non-human primates hard to perform.
A comprehensive knockout collection of maize mutants would complement the existing genome resources to make functional genomics studies in maize simple and rapid.
I like making functional things that have a beautiful form.
Although collagen peptides designed with carefully crafted substitutions such as A12 may provide an attractive alternative choice for treatment of RA, the low numbers of antigen-specific T cells in wild-type mice have made functional T-cell studies in autoimmune arthritis particularly challenging.
They used the low LD analyses to narrow most regions, which will make subsequent functional studies a little easier, and found at least one novel region within GNPDA2 to be associated with BMI risk in African American individuals.
Whilst these data clearly highlight crosstalk between the HIF and NF-κB pathways, the consequences of these associations both in vitro and in vivo and the variation between the cell types studied makes functional interpretation of these existing data difficult.
Another comes from many studies attempting to make functional islet cells from hESCs or hiPSCs as a source of tissue for treating diabetes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com