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Commercially available animals may be castrated at birth, which affects hormonally mediated developmental processes, or may be sexually immature at the time of study making extrapolation of data to adult animals problematic.
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First, there was significant heterogeneity in the studies, making extrapolation of conclusions fraught with error.
This makes extrapolation of the questionnaire data for an extended period of time unreliable.
This preferential selection of younger patients for clinical trials makes extrapolation of the resulting data to elderly patients difficult.
Second, in making extrapolations of bacteremia rates, we made some assumptions that could have biased our adjusted rates.
Several factors make extrapolation of H2O2 production by isolated mitochondria to the in vivo situation invalid.
This variation makes extrapolations of therapeutic concentrations between species difficult.
Sample enrolment was performed strictly according to protocol, thus providing a high-quality data set and making extrapolations redundant.
The geographic distribution of the available studies also makes extrapolation to the whole of Europe questionable.
We have chosen the New Zealand data, as it allows modelling over a patient's lifetime using data that supports nearly half of this life: this makes extrapolation into the lifetime frame less uncertain.
Extrapolation of data in Figure 2A suggest that if the addition of ouabain could have been made instantaneously the fNKCC1 and fNKCC2A fluxes would have been 50 and 81% of the fluxes measured at 5 min respectively.
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