However, scaling fluidized beds for dynamic similarity continues to be challenging because flow hydrodynamics at lab-scale are largely influenced by bed geometry making extrapolation of conclusions to large-scales infeasible.
Therefore, in vitro culture conditions for S. aureus and those in vivo are likely much different, making extrapolation of in vitro results with animal infections models less predictable.
First, there was significant heterogeneity in the studies, making extrapolation of conclusions fraught with error.
For this finding, the exact temporal sequencing of events was not ascertained, making extrapolation of exact cause and effect difficult.
Commercially available animals may be castrated at birth, which affects hormonally mediated developmental processes, or may be sexually immature at the time of study making extrapolation of data to adult animals problematic.
In summary, the ORIGIN trials have included a very selected population characterized by high CV morbidity and mortality in spite of mild hyperglycemia making extrapolation of the results to common forms of type 2 diabetes or prediabetes highly questionable.
