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However, the abovementioned methods often cause dispersion and aggregation of the metallic NPs making difficult to provide enough reproducibility of the characteristics of SERS-active substrates in practice.
However, since the risk is low in the general population, it is not possible to identify which migraineurs will develop a cardiovascular or a cerebrovascular event making difficult to apply preventive measures.
Nevertheless, it should be noted that the probabilistic approach provides an outcome that is quite different from the other methods, thus making difficult to ensure a linear comparison with the other methods.
Most of the articles did not provide data relative to the second molar during the distalization phase, making difficult to compare our data with those from studies that use other appliances, in which the second molar was moved distally by a force acting on the first molar.
Previous research performed in four-stroke engines, has shown how the operating region where gasoline PPC concept can be successfully implemented is largely linked to the octane number of the fuel, making difficult to cover the entire load range with a fixed fuel.
EDM.com doesn't indicate whether posts or social shares are part of a larger marketing campaign paid for by an artist, making difficult to discern what is and isn't sponsored content on EDM.com.
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On the other hand, SFA differentiates true inefficiency from random observation error but it requires making difficult-to-test assumptions on the production relationship between the inputs and outputs.
All this makes difficult to design adequate controllers.
This makes difficult to choose its key determinants from exhaustive specifications.
However, such methodology leads to time-consuming codes that make difficult to optimize all design variables.
This finding makes difficult to get a precise molecular diagnosis and offer patients accurate genetic counselling.
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