We then used the imputed data to make clinical outcome predictions with the published models, and the results were compared with the predictions made using the complete test data with no missing data.
Numerous observational and quasi-experimental studies have shown MDT working to be associated with a range of benefits including better clinical decision-making; clinical outcomes including survival; recruitment to clinical trials; and health professional satisfaction [ 1- 5].
The informations derived on mucinous histology may help researchers and practitioners in designing future studies (e.g., stratification of patients according to the mucinous histology) and in making clinical decisions that will improve the outcome of patients with such histological type.
Managing to regulatory outcome is the antithesis of patient outcome as the regulations were designed without clear clinical outcome corollaries.
This will create clinical outcome measures and biomarkers for clinical trial readiness, necessary to show effect of any experimental therapy.
However, little is known about the effects of this "double paradigm shift" [ 16] toward global CVR and shared decision making on clinical outcomes.
3 14 15 There is also agreement that the heterogeneous nature of tinnitus symptoms and impact can also make clinical research and outcome measurement difficult.
Coagulation markers in the circulation have been shown to increase in patients hospitalized with CAP, although no correlations were made with clinical outcome (28, 34).
Second, our sample size is small making interpretation of clinical outcomes challenging.
In other words, after the initial detailed study and accumulation of information, a basic set of information must be obtained from each new patient in order to adapt the approach before making predictions on clinical outcomes.
Attempts have been made to improve clinical outcomes for frail older people, however no interventions have been developed to specifically reverse the syndrome of frailty.
