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The machinery used to produce millions of antibodies in the immune system can misfire, making cells more likely to become cancerous.
This work suggested that mutations in DNA repair proteins can lead to genomic instability and cancer by making cells more vulnerable to future genetic defects, but scientists still disagree about whether genomic instability causes cancer.
Identifying such cell cycle-dependent features in metastasizing cancer cells could lead to a better understanding of the metastatic process and to possible clinical treatments directed at making cells more shear- and abrasion-sensitive, and therefore, more likely to be killed by the natural hydrodynamic forces of the circulatory system.
In addition, it also is known that making cells more reduced can increase their sensitivity to survival factors (Mayer & Noble, 1994).
Furthermore, if glycolysis is inhibited, the AMPK/mTOR axis inhibits translation of Mcl-1, making cells more susceptible to death ligands.
Together these findings suggest that visual stimulation of tectal neurons increased their propensity to spike and lowered overall cell-to-cell variability and within-group heterogeneity, making cells more alike.
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Adiponectin makes cells more responsive to insulin.
"It makes cells more sensitive to insulin's effects," Sun says.
Oxidative stress accumulates during aging which makes cells more prone to DNA damage.
Depletion of intracellular GSH by buthionine sulfoximine makes cells more susceptible to Cd2+-induced apoptosis.
Although silver was used alone as a therapy in the past, the scientists suspected that both changes might make cells more vulnerable to conventional antibiotics — and they did.
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