Even if drugs are used that primarily affect a single molecule, many drugs potentially have a large set of off-target or side effects making broader changes in physiology that we believe could be visualized using clinical physiological networks.
The Census Bureau wants to make broad changes to its surveys to keep pace with changing notions of race.
The legislation, by McCain and Sen. Russell Feingold (D-Wis)., made broad changes in federal political fundraising.
"Treasury has the power under TARP to make broad changes," Kucinich, Democrat of Ohio, said in a telephone interview.
Still, with a new American administration and a president-elect who has said he intends to make broad changes in foreign policy, there may be opportunities.
The steps will save cash, but like other companies, Macy's is also using the economic downturn as a moment to make broad changes.
In its effort to make broad changes in most aspects of farm policy, Mr. Lugar's bill would also increase money for conservation, remove obstacles to international trade agreements and double the amount of new spending for nutrition and food stamps.
Customers of private water companies routinely pay more for water, and under privatization the people of Atlantic City would lose democratic control of their water and rates, as the people of Flint did when an emergency manager made broad changes to the city's source water in 2014 that resulted in widespread lead contamination.
Effort to Change Money Market Funds Stalls | Attempts to make broad changes to a popular type of money market mutual fund that played a central role in the 2008 financial crisis have been derailed, after a Democratic member of the Securities and Exchange Commission sided with the two Republican members to delay action.
Wal-Mart Stores, the nation's largest retailer and a rare bright star in the grim retailing universe, said Tuesday that it planned to cut 700 to 800 jobs at its headquarters in Bentonville, Ark., as it made broad changes to its operations.
