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Chains of reasoning from secondary causes are often essential to making big discoveries.
But these doctors were on the verge of making big discoveries such as anesthetics, and radical mastectomy for breast cancer.
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The nationalisation of Repsol's shares in YPF in 2012, after the Spanish firm had made big discoveries of shale gas at Vaca Muerta, was a shock.
But what makes big discoveries such as the Higgs (or more recently, the Encode project) is that they are so big.
Reflecting the return of resource nationalism in a country that has recently made big discoveries of shale oil, the group's members enthusiastically chanted before Argentina's president when she announced plans to nationalize YPF.
This can lead to delay in graduation and disappointment for PhD students who fail to make "big discoveries".
It is very difficult to do verifiable and repeatable science under these conditions and this explains why it takes so long to make big discoveries in space.
Well, it is time to start examining molecular sequence data and making some big discoveries, of course.
If Apple makes big changes to discovery, what then?
It must be almost equally discouraging for scientists to see the graph that plots the age at which eminent male scientists make their big discoveries.
But the Department of Energy and Climate Change (DECC) forecasts that over the next 30 years another 14 billion-24 billion barrels of the black stuff will be recovered.There may yet be new finds: Statoil, Norway's national oil firm, has made two big discoveries in its part of the North Sea in the past year.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com