Furthermore, these studies allow us to pursue our goals in two different situations: one, ideal from a statistical point of view, in which the omics data are gathered in the same way both in the training and in the validation sets, and one in which they are gathered with different techniques, making training and validation observations not directly comparable.
The purpose of this article is to describe the development and preliminary validation of Making and Executing Decisions for Safe and Independent Living (MED-SAIL), a brief screening tool for capacity to live safely and independently in the community.
The demonstrations are made theoretically, and validations are made through simulation studies that show that the derived test statistics and their corresponding power functions are very close to each other.
For lack of operating experiences, a verification platform is built to make verification and validation (V&V) of the HMIs.
"Since we understand how the decision-making and validation processes work inside the large companies, we're more able to meet ambitious cost and performance targets".
It is known that prediction rules might act significantly different when applied to a new cohort, making external validation and, if necessary updating, essential [ 16- 19].
We expect that the same is true in the reviewed studies, contributing to the overrepresentation of pQTL candidates in some of them, resulting in a large number of candidates and making experimental validation impractical.
However, with some hit compounds generating resistant- Mtb mutants is not possible, making target identification and validation problematic.
Therefore, adaptations to the ADE questionnaire, such as allowing patients to cluster multiple related ADEs as one overall ADE, need to be made and tested in future validation studies.
The majority of this data has been generated on the Affymetrix platform, potentially making data integration and validation on independent sample sets a possibility.
The rapid evolution of sequencing technology, informatics tools and RMs make validation and optimization a continuous process in which these results represent a particular moment in time.
