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This drug works by preventing C. albicans making a molecule called ergosterol that is incorporated into the cell membrane: without this molecule the yeast cell can't grow.
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It's pretty difficult to make a molecule more light-sensitive without studying its kinetics.
"If you've made a molecule once already, why do you have to keep on making it?
Like atoms binding to make a molecule, pulses of light can bind to make a "light molecule," according to a new study.
As they report online today in Science, they eventually hit on a group of 10 enzymes that allowed the plant to make a molecule called -4' desmethyl-epipodophyllotoxin, a direct precursor to Etoposide and a potent cancer drug in its own right. .
To build the next generation of these selective inhibitors, Vanderbilt's Amit Kalgutkar and Marnett made a molecule that retains aspirin's original acetyl side group, which aspirin transfers to the COX-2 enzyme to destroy it.
These instructions are first copied to make a molecule of messenger RNA (or mRNA for short).
An enzyme called HMG CoA reductase makes a molecule that is used to make cholesterol and many other similar sterol molecules.
DOI: http://dx.doi.org/10.7554/eLife.02674.001 To produce a protein from a gene, the gene must first be transcribed to make a molecule of RNA.
These instructions are copied to make a molecule of mRNA, and a molecular machine known as a ribosome then reads and translates the mRNA to build the protein.
DOI: http://dx.doi.org/10.7554/eLife.04591.001 For a gene to be expressed as a protein, its DNA is first used as a template to make a molecule of RNA, which is then translated to make the protein.
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