Sentence examples for makes unlikely the from inspiring English sources

Although the binding mode of pepstatin A is significantly different from that in other pepsin-like aspartic proteases, its location in the active site makes unlikely the previously proposed hypothesis that HAP is a serine protease.

This finding makes unlikely the possibility that any foreign proteins, including non-eukaryotic proteins, may be present in NB that cannot be explained by simple, physical binding by known proteins to calcium or apatite.

This is probably due to the short evolutionary distance separating these two clades (Fig. S2), which makes unlikely the fixation by positive selection of mutations specific to one clade with respect to the other.

The separation of the beads due to the inhibition of the HGF/MET interaction makes unlikely the emission of light due to the decomposition of singlet oxygen before it can react with the light-emitting beads.

The observation, in our data, of a tendency towards a decreased risk of RA among those with the highest exposure to cosmetics, however, makes unlikely the possibility that nondifferential misclassification of exposure has masked a true positive association between cosmetic use and RA.

There was no difference in age between the two groups (total mean, 43.5 ± 5.5 years) nor in the estimated glomerular filtration rate (total mean, 91.1 ± 14.9 mL/minute), and all patients had a described mutation expressing the classic FD phenotype with severe multiorgan involvement, which makes unlikely the hypothesis that they had a stable or a slowly progressing disease.

BP-mediated TNFα induction was however not suppressed by AhR antagonists, making unlikely the involvement of the typical AhR signalling pathway.

Anti-CGRP mAbs predictably may cross the BBB at a minimum extent, thus making unlikely the hypothesis that they act at sites of action within the central nervous system.

Overall these results make unlikely the involvement of matrix or β1-or β3-integrins in the increased migration of MABs through JAM-A-null endothelial monolayers.

In contrast, no relevant specific autoantibodies to ADAMTS13 were detected, making unlikely the involvement of an autoimmune process in sepsis-associated ADAMTS13 functional deficiency.

The specificity for the homologous recombination effect, and the good classification of CTB and French tumours using the 118 genes regulated differently in response to H2O2 and radiation, make unlikely the confounding effect of age- or ethnicity-related factors.